2013年7月30日星期二

Preparation of ferrous lactate

1 by calcium lactate or sodium lactate solution with ferrous sulfate or ferrous chloride lactic acid powder. Lactic acid was added refined sugar and iron, direct response obtained after crystallization. In order to prevent oxidation, the reaction should be concentrated, crystallized and dried, sealed.
2, the calcium lactate or sodium lactate with ferrous sulfate (ferrous sulfate and the solvent water mass ratio of 2:1) in 45 ~ 50 ℃ and 2.5 ~ 3.0 Ph value 40min reaction conditions can be obtained products.
3, by the addition of ferrous sulfate or Zinc lactate solution plus ferric chloride solution obtained, but also by lactic acid solution was added sucrose and refined iron reaction, and then crystallization derived ferrous lactate.

ferric citrate preparation or sources

1, the citric acid was added to a solution of ferric hydroxide, heated to 60 ℃ less concentrated by evaporation to a slurry obtained by drying the glass temperature.
2, the ammonia solution added to sulfate,buffered lactic acid hydroxide precipitate. Filtered, washed with water to free sulfuric acid. Lactic acid was added, heated with stirring to below 60 ℃, the precipitate is dissolved, followed by filtration. The filtrate was concentrated by heating at 60 ℃ less a syrup on a glass plate coated with a thin layer, the formation of small leaves, peel, tepid, drying derived.

physical properties of ferric ammonium citrate

Appearance: Red brown transparent flakes crystals or crystalline powder.
Solubility: not soluble in ethanol, slowly dissolve in magnessium lactate, very soluble in hot water.
Chemical properties: Calcium lactate solution, by the influence of light and heat gradually reduced to ferrous salts.
Uses: used as a food iron supplements, nutritional supplements. For biscuits, powdered milk and other calcium; radioactive pharmaceuticals used for checking abnormal iron metabolism and hematopoietic function; feed additives.

uses ferric ammonium citrate

Uses a nutritional supplement (iron supplements). For dairy products, bread wheat flour. Also used as an anti-caking agent.
Uses 2 Sodium lactate for the blood drug for the treatment of iron deficiency anemia; can be used as food additives, according to Japan's "food additives officially", the iron content is 16.5% -21.2%. Brown and green products are chemically sensitive material goods, green products are more sensitive than the brown goods. Coated with a green ferric ammonium citrate and potassium ferricyanide (potassium ferricyanide) paper called blue blueprint paper. In the exposure, the citrate ferric originally bivalent, which produce Teng's blue water, it becomes part of the blue light, not the light part is still white, blue and white line drawings can be obtained.
Uses 3 nutritional supplements. Iron supplements, anti-anemia with iron (per oral 1 ~ 2g). Can be added to biscuits, magnessium lactate. Not suitable for coloring foods.
Uses 4 ferric ammonium citrate as a food enhancer of iron absorption than inorganic iron better. China provides for salt and bonbons, usage is 4000 ~ 8000mg/kg; cereals high in iron and its products (daily limit such foods 50g) for 1200 ~ 1350mg/kg; in dairy products and foods for infants and young children 400 ~ 800mg/kg; in grains and their products for the 160 ~ 330mg/kg; in beverages is 70 ~ 140mg/kg.
Use 5 for the pharmaceutical industry
Uses 6 for photographic industry, the pharmaceutical industry
Use 7 for microbial cultures, for example, addicted manganese bacteria are commonly used in laboratory culture medium JFM, where you want to add 10g of ferric ammonium citrate, there is a similar medium to join 2g.

Nature ferric ammonium citrate

Also known as ferric ammonium citrate, citric acid and potassium lactate iron FeC6H5O7 ammonium (NH4) 3C6H5O7 complex salt, its composition varies due to synthesis conditions, there is no exact formula. Brown scaly high iron content of 18.5%, the blood can be used as medicine for the treatment of iron deficiency anemia. Green scaly low iron content, 14.5% to 16%. Both are photochemically sensitive materials, green more sensitive than brown. Coated with a green ferric ammonium citrate and potassium ferricyanide (potassium ferricyanide) paper called blue blueprint paper. In the exposure, the trivalent citrate is reduced to divalent iron, which produce Teng's blue water, it is part of that change to blue light, without light part is still white, blue and zinc lactate drawings can be obtained.
Odorless or slightly ammonia smell and mild iron metallic taste. Deliquescent in the air, by the light effects (hydrolysis). Prone to mildew. Easily soluble in water (1g/0.5m1), nearly neutral solution, insoluble in ethanol and ether. 5% aqueous solution pH of about 5.0 to 8.0.

zinc citrate

Properties: White powder, odorless and tasteless, slightly soluble in water, soluble in dilute calcium lactate and alkali hydroxide.
Method: citrate is obtained by acting on the zinc hydroxide
Scope: zinc supplements for nutrition fortifier, applied to food, health products and medical in
【Description】 apply organic zinc citrate, zinc supplements, irritation of the stomach, the zinc content is high, and in the human body involved in the citric acid cycle, and enhance human digestion and absorption, Ethyl lactate is present in human breast milk only A zinc complexes of zinc than milk more easily absorbed, and the performance is stable for diabetics zinc; zinc citrate, zinc as a common enhancer, which has anti-caking agents and functional, it is especially suitable manufacture supplements and powdered flakes fortified blended foods; iron, zinc, while severe deficiency, zinc citrate can be avoided with the use of iron from antagonism. Because of its chelation, can increase the clarity of juice drinks and fruit juices can be presented refreshing acidity, it is widely used in juice drinks; also widely used in the grains and their products and salt.

Prevention of urinary stones medication potassium citrate

Potassium citrate is the most commonly used drug to prevent stones, the study found urinary pH value and Zinc lactate with the formation of urinary stones have a very close relationship. In acidic urine (pH <5.5), the uric acid solubility is very low, likely to cause uric acid stones; while in alkaline urine (pH> 7), is easy to form calcium phosphate or magnesium phosphate stones. 63% of urinary calculi below normal human urine citrate, potassium citrate and citric acid to provide a large number so as to enhance the pH of the urine, so for uric acid, low calcium citrate poisoning disease and ferrous lactate disease calcium stone disease caused by a very significant therapeutic effect. However, this will result in increased urinary potassium and ammonium ions decrease, which is added as potassium citrate, citric acid only, but also added a potassium sake. Since potassium metabolism in the body very quickly, there is no change in blood potassium levels, so little effect on the body. Uric acid stones from a total daily urine output, oxalate, phosphate, sodium, magnesium, sulfate, and uric acid and other aspects of testing found that it is not affected by the consumption of potassium citrate.

2013年7月29日星期一

The main purpose of potassium citrate

The food industry as a buffer, chelating agents, stabilizers, antioxidants,

emulsifiers, flavoring agents. Can be used for milk and lactic acid powder,

jellies, jams, meats, canned hydrogel snacks,buffered lactic acid, fresh citrus,

etc.; pharmaceutical industry for hypokalemia and potassium depletion and

alkalization of urine. Also can be made efficient compound fertilizer, can

be used for paper, gold and other industries.

Citric acid complexing agent is a food flavor

Citric acid complexing agent is a food flavor, can be complex renal gall bladder into the ureter stones Sodium lactate citrate calcium oxalate stones to make smaller and disappear, can promote fat decomposition, keep your body acid-base balance. Obese people tend to feel tired, because body fat and blood lactate accumulation of increased and so easy, so once the increase in lactic acid, fat will be followed by an increase, people feel lazy, listless and creating a vicious cycle. Citric acid can be reused as energy, so the intake of citric acid, lactic acid can accelerate the decomposition, buffered lactic acid, activate the whole body up and no longer felt limp. Citric acid can reduce the intake of lactic acid in the body, so that the smooth delivery of oxygen and nutrients throughout the body, and further enhance the body's ability to produce energy, to produce the desired physical movement and power. Many well-known athletes are borrowed from the citric acid intake to keep your body in the best condition.
Calcium citrate has anti-clotting effects, prevention and treatment of hypertension and myocardial infarction. So people preferred to use calcium citrate.
Chelating agents, buffers, tissue coagulant, calcium supplements, emulsifying salts.

Effect of calcium citrate

Calcium cations with bones, healthy teeth, anti-inflammatory, analgesic, to maintain normal nerve and muscle excitability, there is treatment of allergic diseases.
Easily lead to calcium deficiency children anorexia, magnessium lactate; difficulty falling asleep, easily awakened, colds; hair thinning; mental retardation; toddler nights, teething teething late or irregular; paroxysmal abdominal pain and diarrhea; buffered lactic acid; chicken.
Calcium deficiency also leads youngsters unable to focus, fatigue, back pain, low immunity, tooth decay or dental dysplasia; pregnant and lactating women cramps, fatigue, joint pain, dizziness, anemia and prenatal hypertension syndrome, edema, and milk secretion.
Calcium deficiency causes skin itch senile elderly, heel pain, lumbar cervical pain, loose teeth, loss, significant kyphosis, height loss, loss of appetite, gastrointestinal ulcers, dreams, insomnia, restlessness, irritability and so on.
According to the 2002 "China National Nutrition and Health" survey report shows that Chinese people are still very serious calcium deficiency situation, the residents daily calcium intake of 391 mg, equivalent to only 41% of recommended intake.

The use of calcium citrate

Food calcium supplements, calcium absorption is better than inorganic. Can be used for a variety of food reinforcement, including infant formula, Sodium lactate, dairy products, solid drinks, sports drinks, milk, soy milk, health care products and cereal products. Of the provisions of the valley and its products can be used, the use of an amount of 8 ~ 16g/kg; milk drinks and beverages in the liquid is 1.8 ~ 3.6g/kg.
Preparation: The milk of lime and magnessium lactate solution, filtering, washing, drying products. You can also shell as raw material, washing, crushing, calcining made of lime, and then with citric acid solution and then filtered, washed, dried product.

Calcium citrate calculation

A hydrophobic parameter calculation reference value (XlogP):
2, the hydrogen Lactic acid: 6
3, the hydrogen bond acceptors: 18
4, rotatable bonds: 4
5, tautomers Quantity:
6, topological molecular polar surface area (TPSA): 285
7, the number of heavy atoms: 33
8, the surface charge: 0
9, Calcium lactate: 211
10, isotope atomic number: 0
11, to determine the atomic stereocenter number: 0
12, uncertain atom stereocenter number: 0
13 to determine the chemical bond stereocenter number: 0
14, uncertain bond stereocenter number: 0
15, covalently bonded unit: 9

Two calcium citrate

Chinese Synonyms: two calcium citrate; Calcium lactate; calcium citrate tetrahydrate; calcium citrate
English name: Calcium citrate
English Synonyms :1,2,3-Propanetricarboxylicacid ,2-hydroxy-, calciumsalt (2:3); 2,3-propanetricarboxylicacid ,2-hydroxy-calciumsalt (2:3); acicontral; citricacid, calciumsalt (2:3) ; lactic acid powder; tribasiccalciumcitrate; TRICALCIUM DICITRATE; citric acid sesquicalcium tetrahydrate
CAS No. :813 -94-5; 7693-13-2
MF: C12H10Ca3O14
Molecular Weight: 498.43
EINECS No. :212 -391-7
Mol File :813-94-5. Mol

2013年7月28日星期日

Calcium citrate role

Citric acid complexing agent is a food flavor, can be complex renal gall bladder into the ureter stones soluble magnessium lactate calcium oxalate stones to make smaller and disappear, can promote fat decomposition, keep your body acid-base balance. Obese people tend to feel tired, because body fat and blood lactate accumulation of increased and so easy, so once the increase in lactic acid, fat will be followed by an increase, people feel lazy, listless and creating a vicious cycle. Citric acid can be reused as energy, so the intake of citric acid, lactic acid can accelerate the decomposition, fatigue, activate the whole body up and no longer felt limp. Citric acid can reduce the intake of lactic acid in the body, so that the smooth delivery of oxygen and buffered lactic acid throughout the body, and further enhance the body's ability to produce energy, to produce the desired physical movement and power. Many well-known athletes are borrowed from the citric acid intake to keep your body in the best condition.
Calcium citrate has anti-clotting effects, prevention and treatment of hypertension and myocardial infarction. So people preferred to use calcium citrate.
Chelating agents, buffers, tissue coagulant, calcium supplements, emulsifying salts.

Calcium citrate Precautions

Calcium lactate with bones, healthy teeth, anti-inflammatory, analgesic, to maintain normal nerve and muscle excitability, there is treatment of allergic diseases.
Easily lead to calcium deficiency children anorexia, the partial eclipse; difficulty falling asleep, easily awakened, colds; hair thinning; mental retardation; toddler nights, teething teething late or irregular; paroxysmal abdominal pain and diarrhea; X or O-type legs ; chicken.
Calcium deficiency also leads youngsters unable to focus, fatigue, back pain, low immunity, tooth decay or dental dysplasia; pregnant and lactating women cramps, fatigue, joint pain, magnessium lactate, anemia and prenatal hypertension syndrome, edema, and milk secretion.
Calcium deficiency causes skin itch senile elderly, heel pain, lumbar cervical pain, loose teeth, loss, significant kyphosis, height loss, loss of appetite, gastrointestinal ulcers, dreams, insomnia, restlessness, irritability and so on.
According to the 2002 "China National Nutrition and Health" survey report shows that Chinese people are still very serious calcium deficiency situation, the residents daily calcium intake of 391 mg, equivalent to only 41% of recommended intake.

Calcium citrate application and configuration

Food calcium supplements, calcium absorption is better than inorganic. Can be used for a variety of food reinforcement, including infant formula,
 magnessium lactate, dairy products, solid drinks, sports drinks, milk, soy milk, health care products and cereal products. Of the provisions of the valley and its products can be used, the use of an amount of 8 ~ 16g/kg; milk drinks and beverages in the liquid is 1.8 ~ 3.6g/kg.
Preparation: The milk of lime and Lactic acid solution, filtering, washing, drying products. You can also shell as raw material, washing, crushing, calcining made of lime, and then with citric acid solution and then filtered, washed, dried product.

Calcium citrate computational chemistry data

1 hydrophobic parameter magnessium lactate reference value (XlogP):
2, the hydrogen bond donor: 6
3, the hydrogen bond acceptors: 18
4, rotatable bonds: 4
5, tautomers Quantity:
6, topological molecular polar surface area (TPSA): 285
7, the number of heavy atoms: 33
8, the surface charge: 0
9, Complexity: 211
10, isotope atomic number: 0
11, to determine the atomic stereocenter number: 0
12, uncertain atom stereocenter number: 0
13 to determine calcium lactate bond stereocenter number: 0
14, uncertain bond stereocenter number: 0
15, covalently bonded unit: 9

Calcium citrate Introduction

Chinese Synonyms: two calcium citrate; citrate calcium; calcium citrate tetrahydrate; calcium lactate
English name: Calcium lactate
English Synonyms :1,2,3-Propanetricarboxylicacid ,2-hydroxy-, calciumsalt (2:3); 2,3-propanetricarboxylicacid ,2-hydroxy-calciumsalt (2:3); acicontral; citricacid, calciumsalt (2:3) ; citrical; tribasiccalciumcitrate; TRICALCIUM DICITRATE; citric acid sesquicalcium tetrahydrate
CAS No. :813 -94-5; 7693-13-2
MF: C12H10Ca3O14 [1]
Molecular Weight: 498.43
EINECS No. :212 -391-7
Mol File :813-94-5. Mol

Calcium citrate nature

Solubility: 0.1 M HCl: 0.01 M at 20 ° C, clear, colorless
White crystalline powder, calcium lactate, slightly hygroscopic, slightly soluble in water, soluble in acid, almost insoluble in ethanol, crystal water heated gradually lose moisture as 100 ℃, 120 ℃ when fully dehydration.
Stability
Stable under normal temperature and magnessium lactate.
Ecological data
Water is usually not hazardous, without proper governmental permits a hazardous material surroundings.

Calcium citrate

Calcium citrate is insoluble in water (0.1g/100mL, 25 ℃). Slightly hygroscopic. Heated to l00 ℃ gradually lose crystal water. ADI value does not make special provision (FAO / WHO, 1994). lactic acid powder, calcium supplements as food, good calcium absorption than inorganic. Chinese regulations for grains and their products, usage is 8 ~ 16g/kg in milk beverages and ferrous lactate is 1.8 ~ 3.6g/kg. Citric acid complexing agent is a food flavor, can be complex renal gall bladder into the ureter stones soluble calcium citrate calcium oxalate stones to make smaller and disappear, can promote fat decomposition, keep your body acid-base balance.

2013年7月26日星期五

Accumulation of lactic acid production

Our body needs to survive most of the energy from the sugar. Blood glucose as needed to the various organs of the combustion heat generated. This process will produce water, carbon dioxide and pyruvic acid, lactic acid powder and lactic acid generated after hydrogen bonding. If the body energy metabolism can be normal, no accumulation of blood will be taken to the liver, and further decomposed into water and carbon dioxide, heat, fatigue is eliminated.
If the motion is too intense or prolonged, or physical decomposition of lactic acid deficiency in essential vitamins and minerals, the body too late to be processed lactic acid, resulting in the accumulation of lactic acid. Too much Lactic acid will weakly alkaline body fluids acidic, affecting the smooth absorption of nutrients and oxygen to cells, weakening the normal function of cells. Accumulation of lactic acid in muscle contraction will occur, thus squeezing blood vessels, making poor blood flow, resulting in muscle aches, chills, headache, heavy flu.
Accumulation of lactic acid in the initial cause soreness and fatigue, if the long-ignored, resulting in acidic and may cause serious illness.
Some people used to sleep late on holidays to eliminate fatigue, which is invalid. Use chemicals only seek temporary relief, but also have side effects. The correct way is to use the appropriate exercise, especially stretching exercises to relax the muscles, promote blood circulation, select the equalizer light nutrition, especially foods rich in B vitamins, plus the quality of sleep, it will get the best effect.

Ferrous lactate field

1, widely used in food, beverages, dairy products, magnessium lactate, nutrition, medicines, etc.2, nutritional supplements (iron supplements). Adult daily requirement of 16mg, the baby was 6mg (Japanese standard). Iron used to fortify milk added when about 6mg/100g. For wheat flour, biscuits, bread, the use of an amount of 2 ~ 3mg/100g. Strengthening of the goods rat milk, the absorption rate (for iron) is very strong. Coloring modifiers.
3, ferrous lactate is a good food enhancer of iron absorption effect is better than inorganic iron. China provides for bonbons, usage is 600 ~ 1200mg/kg (iron, the same below); also be used for dairy products and buffered lactic acid, usage is 60 ~ 100mg/kg; also be used for grains and their products , using an amount of 24 ~ 48mg/kg; also for beverages, with an amount of 10 ~ 20mg/kg.
4, ferrous lactate food and feed additives, is the treatment of anemia drugs. Adult daily requirement of 16mg, the baby is 6mg. As an enhancer of iron, the United States provides an amount of flour 3mg/100g, Bread dosage 2mg/100g, powdered milk for 6mg/100g. Photolabile iron compounds, iron ions react with the colored antioxidant when in use should be noted.

Precautions Lactic acid ethanol

Storage Precautions: Store in a cool, ventilated warehouse. Keep away from fire and heat. Keep container tightly closed. Should oxidants, magnessium lactate, bases stored separately and avoid mixing reservoir. Explosion-proof lighting, ventilation facilities. Prohibit the use of easy to produce sparks of mechanical equipment and tools. Storage areas should be equipped with spill response equipment and materials suitable host.
Handling Precautions: closed operation, full ventilation. The operator must go through specialized training, strict adherence to rules. Proposed operators wear self-absorption filter respirators (half-mask), wearing chemical protective safety glasses, wear anti-static overalls, wearing rubber gloves. Keep away from fire, heat, workplace smoking. Use explosion-proof ventilation systems and equipment. Prevent vapor leakage into the workplace air. Avoid contact with oxidizing agents, Sodium lactate, alkalis contacts. Handling of light when light unloading, packaging and containers to prevent damage. Equipped with the appropriate variety and quantity of fire equipment and emergency equipment leakage. Empty containers may be harmful residues.

Lactate areas

1.Do emulsifiers, humectants, flavor-improving agent, quality-improving agent, antioxidant synergist pH adjusting agent is widely used in meat and poultry food processing industry, to enhance the flavor, inhibit pathogens in food Bacterial growth and prolong the shelf life of products;
2. zinc lactate as a food preservative, flavoring agent, antifreeze, moisturizing agent, in foreign countries portion Of substitution of sodium benzoate as a preservative used in the food industry. Than lactate, sodium benzoate, citric acid Sodium sorbate, calcium lactate, etc. There is not the same match advantage. Especially in meat products has the following significant results : 1, to extend the shelf life: extended from 30 to 100%, or even longer; 2, inhibition of pathogenic food Bacteria such as: HT Escherichia coli, Listeria monocytogenes bacteria, Clostridium botulinum growth of bacteria such as buds, Thereby increasing food safety; 3, enhance and maintain the flavor of the meat; 4, not as a salt Can reduce the amount of sodium chloride, sodium lactate, while people on low-salt heart disease, hypertension, kidney Patients, more secure. For example, preparing a balanced fitness potassium and sodium salts.

Lactic acid adenosine triphosphate

Adenosine triphosphate is split in the release of energy is that it releases a proton. These protons are leading causes of Lactic acid. In the intense aerobic metabolism during exercise can not guarantee the production of ferrous lactate, so anaerobic metabolism begins. This process can produce a large number of adenosine triphosphate, adenosine triphosphate which the release of a large number of protons in the decomposition, reducing the pH of the tissue, causing acidosis. This is a strong muscle soreness during exercise one of many reasons. It was considered by the strong ion concentration gradient can cause lactic acidosis, but the study of this process is imperfect, it is unclear whether there.

Use of lactic acid

seasoning, the increased acidity of lactic unique delicious food, in salads, soy sauce, vinegar, seasoning adding a certain amount of Zinc lactate, can maintain the stability of the microbial products, security, while making the milder taste ;As a mild lactic acidity is moderate, but also as a careful deployment of soft drinks and juices preferred acidifying agent;in the brewing of beer, adding the appropriate amount of calcium lactate to adjust the pH to promote both glycosylated, is conducive to yeast fermentation, improve the quality of beer, but also increase the beer flavor, extend shelf life. In the liquor, sake and wine used to adjust the pH, to prevent bacteria growth, enhance sour and refreshing taste; 5. Buffered lactic acid can be used in hard candy, fruit candy and other confectionery products, moderate acidity and sugar conversion rate. Lactic acid powder can be used on all kinds of candy powder, sour agent as a powder;
 Natural Lactic acid is a natural inherent ingredient in dairy products, dairy taste and it has good anti-microbial effect, has been widely used in the deployment of yogurt cheese, ice cream and other foods, dairy sour agent as acclaimed;

enzymatic conversion of pyruvate

Lactate dehydrogenase from the highest activity of Lactobacillus DSM20196 confusion cells obtained in potassium lactate dehydrogenase, a non-optically active pyruvate as substrate D-lactic acid can be obtained.
Industrial production of lactic acid fermentation method and the method is mainly synthesis. Because fermentation process is simple, abundant raw materials, develop and become more mature earlier lactic acid production methods, lactic acid production accounts for about 70 or more, but long cycle, only batch or semi-continuous production and quality of domestic Sodium lactate fermentation to international standards. Chemical method can achieve large-scale continuous production of lactic acid and lactic acid synthesis has also been the U.S. Food and Drug Administration (FDA) approval, but the raw materials are generally toxic, does not meet the requirements of green chemistry. Enzymatic process is complex, and its industrial application needs further study.

2013年7月25日星期四

standard milk

The choice of skimmed milk powder must meet GB5411 standards, using the best quality product,Zinc lactate, no impurities, no antibiotics and preservatives bacterial count of less than 20,000 / g, reducing lactic acid is less than 18 oT. Emulsion formulation dissolved by alcohol test done, no flocculent precipitate before use. Emulsion required after buffered lactic acid sterilization thermal coagulation diffusion test, a drop of water inside the emulsion to the surface of the cylinder and observe the spread of its thermal coagulation, the general diffusion of fast, quickly dissolved in water without sinking granulated milk point preferred, otherwise The lactic acid fermentation products will be made soon precipitation phenomenon, affecting the appearance and taste is also good.

types of milk

In actual production, the Lactic acid fermentation of substrates required than using whole milk or skimmed milk in the milk fat is good. Because skim milk powder composition uniformity, easy to operate, suitable for cultivation of lactic acid bacteria, and whole milk and milk fat in the fat component will prevent lactic acid fermentation, dissolved after sterilization, fat floating on the surface of the emulsion, the lactic acid bacteria with the outside air isolated, anaerobic conditions to form lactic acid bacteria and anaerobes corporations, but in absence of oxygen will be affected, lactic acid fermentation is slow, and if not add other materials, the products made of a layer of floating fat, effect Product appearance and magnessium lactate, if you use the fat milk products may also cause precipitation. But Ruoyin skimmed milk supply shortage, you can skim milk powder and butter milk powder in the ratio of not less than 2:1 mixture of lactic acid fermentation using such may be slightly slow, but in the conditions allow appropriate to extend the fermentation time (generally by the 5 ~ 6d extended to 7 ~ 8d), you can solve this problem.

lactic acid tone perfumer

Of acid: lactic acid bacteria beverages in order to improve the taste, the need for sugar to acid ratio to be adjusted to meet the requirements of people's tastes, a certain amount of sugar and acid. Sugar and milk protein has a better affinity magnessium lactate can increase milk protein in the beverage The stability, in a stable and sweetening agents mixed with the fermented milk, based on the use of different acids blending acidity, type and amount of acid acidulant selection experiment results show that citric acid, lactic acid, tartaric acid mixed with the resulting Product moderate soft sour sweet tasty so choose products with citric acid: lactic acid: tartaric acid = 3:3:2 mix of acid to a pH of about 4.0, the use of composite sour dose of about 0.25%. Perfumer: According to the requirements of Ethyl lactate bacteria beverage flavor, you can choose the appropriate flavor. To compensate for the lack of milk butter flavor, may be appropriate to add butter flavor; to reflect the fruit flavors, you can choose the appropriate fruit flavors; flavor dosage should be limited to reflect the fruit flavors. Feed temperature as low as possible when added, should generally be below 20 ℃ avoid aroma loss, usually added in an amount of 0.06% ~ 0.08%. In order to make lactic acid bacteria beverage with natural fruit flavors, you can add 1% to 2% natural pure fruit juice, instead of flavor, taste better, but also to meet consumer demands for green food .

lactic agent selection

1 choice of chelating agent. During the fermentation process, the pH value decreased to less isoelectric point of casein, the calcium ion in free state, the bridging effect. Can cause precipitation of casein, affecting the stability of the beverage, so need to choose an appropriate chelating agent chelating total Ca2 + Ca2 + chelator used with phosphate and lactic acid powder, the screening process was carried out Take skimmed milk 25mL, then adding a chelating agent solution appropriately diluted after mixing be adjusted with citric acid, flocculation occurs when the system tilting stop adding acid, NaOH solution titrated with 0.1 standard value of its acidity, acidity higher values ??indicating Ca2 + chelator chelating ability is stronger, the results show that, NaH2PO4 strongest chelating ability, so choose NaH2PO4 as a chelating agent. (2) the choice of stabilizer. Since lactic acid bacteria beverage stabilizer on taste and stability of very large, so the present process commonly used stabilizer (PGA, acid CMC, reducing glue, sodium alginate, etc.) were screened for the stabilizer agent and three times zinc lactate, Select various stabilizers were 0.4% mass fraction, dissolved with warm water added to milk, the comparison by the line selection, the results show that, PGA stabilizing effect on the fermented milk is best, but due to high cost, and therefore need to be considered other stabilizers composite applicable, restore the CMC glue and acid stabilizing effect little difference, in addition to the stabilizing effect of sodium alginate is poor, so you can consider choosing PGA and acid CMC and restore gum as a composite stabilizer.

lactic operating points

1 raw lactate degree requirements do not exceed 20 ° T, requires no antibiotics, magnessium lactate and other antibacterial substance. 2 sterilization, cooling, high temperature short time sterilization (90 ~ 95 ℃ 30 min), rapidly cooled to 43-45 ℃. 3.3 inoculation, fermentation
????3 ferment choice. In the lactic acid fermentation process, cocci and bacilli symbiosis mixed fermentation can significantly better than single fermentation, metabolites Because the two different bacteria, with the different strains, and the mixing ratio of the acid and the formation of flavor components has a significant impact. Technical strains ferment milk drinks selection order of acid production, Sodium lactate capacity of incense, hydrolyzed protein capacity after fermentation acid, producing sticky ability. 4 inoculation, fermentation. The fermentation agent is mixed with the raw milk, fermented at 43 ℃ 2-3 h, when the acid fermentation of milk to achieve a pH of 4.6-4.7 starts to condense, stop fermentation. 5 cool. After fermentation, the resulting fermented milk with a plate heat exchanger rapidly cooled to below 30 ℃. 6 mixed. The additives and sweeteners (0.2% sucrose ester and white sugar, the sugar content of 12% final) dissolved completely using plate heat exchanger is heated to 90 ℃ sterilization and then cooled to below 30 ℃, then add it to the fermentation emulsion obtained after fermentation stir.

lactic acid bacteria beverage trends

In recent years, lactic acid drinks with tasty, healthy, convenient and stylish features to become the new darling of the market.Calcium lactate bacteria beverage in Japan is in its birthplace enduring state. Strengthen the health factor is a major lactic acid bacteria beverage development. In order to adapt diet fitness needs.lactic acid powder bacteria beverage is milk or milk fermented with lactic acid as the main raw material, with accessories and water blend drinks. On this basis, you can add a variety of nutritional supplements, made from various types of nutritional health drink. But it also is an important source of beneficial bacteria in maintaining balance of intestinal flora, the treatment of gastrointestinal disorders have a certain effect. Currently, the lactic acid bacteria beverage research focus is primarily on the stability of product technology and new products development, the study results show that the addition of lactic acid bacteria beverage stabilizer is to improve the stability of a effective way. Add different types of nutrients to produce a new type of lactic acid bacteria beverage is becoming a trend

live Lactobacillus beverage production methods

Live Lactobacillus beverage production method is based on skimmed milk powder, glucose, with a certain formula, access lactic acid powder bacterium culture fermentation, no sterilization is completed, homogenized and then mixed with the syrup, the final blend of water, which is comprising a lot of live lactic acid bacteria fermented beverages. Due to lactic acid fermentation metabolite has a unique taste and inhibition of harmful bacteria, so do not add any preservatives, additives, stabilizers, taste natural, concrete mixing machine, healthy. It is different from the conventional type of acid milk beverage, a method of acid type is sugar, stabilizers, fruit juice, flavors, preservatives, organic acids such as diluted milk was added to the deployment of, it does not contain live Lactobacillus

How to drink healthy yogurt

First, do not heat
Experts said that the activity of probiotics potassium lactate, if the heating or diluted with water, will be a lot of death, not only lost the unique taste and nutritional value will be wiped out, it is recommended that consumers drink yogurt is best not to do anything before. " processing. "
Second, do the same clothes with certain drugs
Many people know that drugs can not and tea with the service, because it will help reduce efficacy. But few consumers know that if drugs and yogurt drink with sinks, are also bad for your health. According to experts, chloramphenicol, erythromycin and other antibiotics, Calcium lactate and treatment of diarrhea in some drugs, kill or destroy the activity of probiotics in yogurt.
Third, not fasting yogurt
Just like regular milk to drink, like fasting, fasting drink yogurt not be adverse physical health, but will make the yogurt has a role in health care had weakened. Select it after dinner drink yogurt, probiotics can play a full part to help gastrointestinal motility, and resist harmful bacteria, so that more healthy gut.

how to identify strains

Yogurt contains bacteria, determine the health value of yogurt. Good bacteria allows fully fermented milk thus produce good taste. However, the reporter visited Guangzhou last week, major supermarkets and found that yogurt, probiotic dairy drinks and other varieties and brand are very many, and magnessium lactatecontained a number of probiotics names. Consumers are buying yogurt has told reporters that the strains indicated on the package have not heard of most of their own, so the choice is difficult to distinguish between what they really want yogurt products.

In this regard, industry experts said most of the yogurt contains Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus bulgaricus and other species,buffered lactic acid, there are some consumers have never seen before yogurt strains formulations, such as a brand Chang's light yogurt packaging that is labeled "composite ABB bacteria." "In fact consumers of these species are not" strangers ", such as" compound ABB bacteria "is a mix of several common species, such as which is called" A fungus "is Lactobacillus acidophilus, the main function is conditioning the small intestine, which will help nutrient absorption; while "BB bacteria" is the Lactobacillus and Bifidobacterium longum combination of the two, can inhibit the growth of harmful bacteria, the normal regulation of intestinal peristalsis, promote the body's digestion and absorption. "

election yogurt bacteria should take a closer look

First, to identify the species
Experts say there is a lot of milk (milk), ferrous lactate, lactic acid (citric acid), spices and preservatives such as processing preparation of the "milk yogurt," because with the dead bacteria, so I do not have yogurt viable health effects, carefully identify the time of purchase. "According to state regulations, the activity of lactic acid bacteria of lactic acid bacteria beverages must be at least 10 quadrillion months, so people buy when you can first see if there is no such labeling, and the number of lactic acid bacteria indicated whether the target."
Second, to identify bacteria
Yogurt contains bacteria, determine the health value of yogurt. Good bacteria allows fully fermented milk thus produce good taste. However, the reporter visited Guangzhou last week, major supermarkets and found that yogurt, probiotic dairy drinks and potassium lactate and brand are very many, and which also contained a number of probiotics names. Consumers are buying yogurt has told reporters that the strains indicated on the package have not heard of most of their own, so the choice is difficult to distinguish between what they really want yogurt products.
Third, we should choose freezers
According to experts, lactic acid bacteria at 0 ℃ to 7 ℃ environment will stop growing, and with the ambient temperature, the lactic acid bacteria multiply rapidly, rapid death, then no viable yogurt became acidic dairy products, its nutritional value will be greatly reduced. Yogurt in the open, it is best to drink within 2 hours.

2013年7月24日星期三

The benefits of lactic acid bacteria drink

1) lactic acid bacteria can inhibit the body lead to aging and disease-causing growth of harmful bacteria, improve immune system function, ferrous lactate.
2) to improve gastrointestinal function, cancer prevention Chang, promote appetite, enhance nutrient absorption materials.
3) helps to rid the body of waste, liver detoxification beauty.
4) reduce blood cholesterol, prevent diabetes.
5) is the best source of calcium lactate prevent osteoporosis.
6) rich in protein can help improve sleep quality and relieve stress.
7) Bifidobacterium phosphorus produced proteolytic enzymes, can easily absorb protein suckling, and promote the healthy development of infants and young children.

lactic acid bacteria beverage categories

 Lactobacillus beverage on the market of two types: one is with the activity of lactic acid bacteria beverage, referred to active milk, lactic acid bacteria beverage that contains live Calcium lactate bacteria. As requested, the activity per milliliter of milk should not be less than the number of live lactic acid bacteria 1,000,000. When people are drinking the drink, the lactic acid bacteria to the colon moves along the digestive tract, because it has the activity of lactic acid bacteria in the human large intestine rapidly, while the acid, thereby effectively inhibit spoilage and pathogenic bacteria to multiply and survive, The buffered lactic acid bacteria are harmless. This drink requires 2 ~ 10 ℃ lower storage and marketing, sealed package active milk shelf life of 15 days. Another means of lactic acid bacteria beverage, which is commonly referred to as lactic acid bacteria beverage, generally do not have the activity of lactic acid bacteria in the production process in which the heating phase has been sterile kill. This drink can be stored at room temperature and sales, but also the effect of lactic acid bacteria does not exist. We consumers buy these drinks be sure to see product labeling and ingredients, distinguish between good lactic acid drinks, non-reactive and active lactobacillus drink milk, figuring out their nutritional value.

2013年7月23日星期二

lactobacillus tablets precautions and drug interactions

1. The Drug Hypersensitivity, allergic caution. 2 If overdose or serious adverse reactions should seek medical care ferrous lactate. 3. The drug prohibition of the use of property changes. 4 Make the medicine where children can not reach. 5 Children must be under adult supervision. 6 If you are using other drugs, the use of the drug before you consult a physician or pharmacist.
Drug Interactions
1 bismuth, tannic acid, medicinal charcoal, tinctures, etc. can absorb the drug should not be shared. 2 used simultaneously with other drugs may occur drug interactions, please consult your physician or pharmacist. The drug in the intestine to form a protective layer to prevent pathogens,lactic acid powder; stimulates intestinal secretion of antibodies, increased intestinal immunity; selectively kill intestinal bacteria, protecting promote the growth of beneficial bacteria; regulating intestinal electrolyte, water balance; promote gastric secretion, enhance digestive function.

lactobacillus tablets use

Lactobacillus tablets should not be combined with antibiotics, some people suffer from abdominal pain, bloating or gastrointestinal discomfort, and often prefer this drug with gentamicin, norfloxacin (norfloxacin) and other antibiotics taken together, that can be adjusted so that both gastrointestinal function, and can be sterilized, it will enhance the therapeutic effect. In fact,magnessium lactate can not be combined with antibiotics for. 
Because Lactic acid are biologically active substances, antibiotics inhibit or reduce its biological activity, reduce the efficacy of the drug. In addition to these drugs, sulfonamides, furazolidone drugs, nor with the drug combination. If the drug really necessary in the use of the process in combination with other drugs, you need to consult a doctor, so as not to affect the efficacy. Third, lactobacillus tablets should not be with a convergence effect of the drug combination when people got diarrhea enteritis or improper diet, often would lactobacillus tablets with tannic acid protein, bismuth carbonate, medicinal charcoal, grease, etc. Compound Fenno drug combination . These drugs are adsorbed or convergence effect, can prevent intestinal abnormal fermentation (ie, protein in the intestine corruption, induced a large number of pathogenic bacteria to grow), to reduce the absorption of toxins in the intestine and the intestinal mucous membrane irritation,Ethyl lactate , and thus play antidiarrheal effect. However, these drugs adsorption and convergence, will reduce the activity of lactic acid bacteria, so if the lactobacillus tablets in combination with these drugs but will reduce its efficacy. In addition, Juefu lactobacillus tablets after, to use warm water in the mouth of residual drug paste, water temperature not exceeding 40 degrees Celsius better. At this point, we must pay attention to the water temperature is not too high, because the water temperature is too high is easy to suppress the activity of lactic acid bacteria and reduce efficacy.

lactobacillus tablets

ferrous lactate, developed in recent years to digest non-prescription drugs, commonly used in indigestion, enteritis, the treatment of children with diarrhea and other illnesses. Its pharmacological effects are: ① in the intestinal wall can be formed on the surface protective layer, effectively blocking pathogens and viruses; ② can stimulate the intestinal tract to produce antibodies, thereby improving their intestinal immune function; ③ able to protect and promote the intestine growth of beneficial bacteria that selectively kills the pathogen; ④ can regulate intestinal water and electrolyte balance; ⑤ can promote gastric acid secretion, enhance digestion. When using lactobacillus films, should be strictly in accordance with the right approach to take, if unauthorized changes taking method, it will weaken calcium lactate. So, taking lactobacillus films, should pay attention to what matters it? First, lactobacillus tablets to chew some people feel Juefu drug smells bad, it is direct water delivery service. In fact, doing so on the efficacy of the play is very unfavorable.
Because lactobacillus tablets in the mouth when chewed saliva sufficiently mixed to form a paste, which makes the drug into the gastrointestinal tract to the rapid decomposition, directly enhance the acidity of the intestines, which can inhibit the propagation of intestinal pathogens . Moreover, the fermentation of lactic acid can be reduced saliva and gas effects play a role in the drug speed.

D-lactic acid in the polylactic acid biodegradable material application

Lactic acid is polylactic acid bioplastics (polylactide, PLA) materials. Calcium lactate (lactic acid) depends on the physical properties of D, L two isomers composition and content. The racemic D,potassium lactate synthesized racemic D, L-polylactic acid (PDLLA) is amorphous structure, poor mechanical properties, degradation time is shorter, and the contraction occurs in the body, the contraction rate of 50 % or more, the application has been limited. L-polylactic acid (PLLA) and D-polylactic acid (PDLA) regular arrangement of the segment, crystallinity, mechanical strength and melting point so far over PDLLA.

lactobacillus

Lactobacillus refers to lactic acid ferrous lactate of sugars main product of a class of non-spore, Gram-positive bacteria in general.
All from glucose or lactose to produce lactic acid fermentation process referred to as lactic acid bacteria. This is quite a heterogeneous group of bacteria, the current can be divided into at least 18 genera, there are more than 200 kinds. Except for a very few exceptions, most of which are essential to the human body and has important physiological functions of bacteria, which are widely present in the human gut. Has now been confirmed by biologists at home and abroad, intestinal lactobacillus very closely with the health and longevity of a direct relationship.
Lactic acid bacteria are a group from fermentable carbohydrates produce large amounts of lactic acid in Gram-positive bacteria known, widely present in the human, livestock, poultry intestinal tract, many foods, materials and a few clinical samples. Lactic acid bacteria can not only improve the nutritional value of food, improve food flavor, improve food preservation and added value, and, in recent years, the special physiological activity of lactic acid bacteria and nutritional functions, are increasingly attracted attention.Ethyl lactate show that lactic acid bacteria can regulate the body's normal flora of the gastrointestinal tract, maintaining micro-ecological balance, improve food digestibility and biological value, lower serum cholesterol, control endotoxin, inhibit the intestinal bacteria growth and reproduction of corruption and corrupt generation products, manufacturing nutrients, stimulate tissue growth, and thus the body's nutritional status, physical function, cell infection, drug effects, toxicity, immune response, tumors, aging process, and other produce sudden emergency response effect. Thus, the physiological functions of lactic acid bacteria and the body's life activities are closely related. It can be said that if lactic acid bacteria stop growing, healthy humans and animals, it is difficult to survive.Sodium lactate because of this, lactic acid bacteria are widely used in light industry, food, pharmaceutical and feed industries and many other industries on .
Lactic acid bacteria present in the human body is a probiotic. Lactic acid bacteria can ferment carbohydrates into lactic acid, hence the name. Probiotics can help digestion, helps the healthy human gut, it is often regarded as healthy foods, add in the yogurt within.

types of lactic acid bacteria

Lactic acid bacteria can be divided into two categories. One is of animal origin lactic acid bacteria, a class of plant origin lactic acid powder bacteria. Because animal origin from animal species often result in a relatively unstable state, its biological effects are relatively unstable, and in a lot of food, it is easy to cause human animal protein allergy, that rejection. The plant-derived lactic acid bacteria, because the body easily recognized from the plant, regardless of how much the amount of intake, the body does not produce variant protein rejection, and the ratio of plant origin lactic acid bacteria of animal origin are more dynamic, more than the animal eight times the number of sources Arrival human intestinal colonization, and thus play its strong and stable biological effect.
In fact, the ordinary lactic acid bacteria, vitality very weak, they can only be in a relatively restricted magnessium lactate survive, a but off these environments, which itself would have been destroyed. Only through a special process of lactic acid bacteria to reach the gut. Lactic acid bacteria into the intestines, you must have more than the number of strong vitality in order to exert their biological effects. How to develop a strong vitality and a high concentration of lactic acid bacteria, microbes become today's scientists to pursue the dream.

finishing activities, sleep reduce lactic acid accumulation

Organize activities to eliminate fatigue, potassium lactate physical recovery method. Coaches, athletes should be given adequate attention. After strenuous exercise to organize activities that enable the cardiovascular system, respiratory system remains at a high level, is conducive to repay the oxygen debt owed movement. Organize activities to relax the muscles can be avoided due to local circulation disorders affect metabolic processes. Organize activities shall include jogging, gymnastics and various respiratory muscles stretching exercises. Doing stretching exercises after exercise can eliminate muscle spasms, improve muscle blood circulation, relieve muscle soreness and stiffness levels, eliminating local fatigue in the prevention of sports injuries occur also has a good effect.
Sleep is fatigue, a good way to recuperate. The excitement of the cerebral cortex during sleep decreased catabolism is at the lowest level, while anabolic processes is relatively high, is conducive to the accumulation of energy in the body.Calcium lactate athletes during training in peacetime, should be a day 8-9 hours of sleep. In the large amount of exercise and during the game, the sleep time should be extended. Young athletes sleep time should be longer than adult athletes, must ensure that there are 10 hours of sleep a day. If on the afternoon arrange for the training, there should be appropriate noon nap time (1.5 to 2 hours).

How to avoid accumulation of lactic acid

1 exercise in moderation, pay attention to the rhythm of the foot, a hot shower
2 Do not put the gear ratio change at large, so the muscles to do the work is great, buffered lactic acid produced by anaerobic respiration big, so try to avoid the chance of excessive load
3 Put the gear ratio to put smaller, with a brisk pedaling frequency, so the magnessium lactate can be taken away as much as possible, but this is the way to relax and lead acid
4 cycling process, reducing the chance to stop pedaling, because it can easily lead to accumulation of lactic acid accumulation can not be timely to reduce

2013年7月21日星期日

Ethyl lactate computational chemistry data

A Ethyl lactate hydrophobic parameter calculation reference value (XlogP): 0.2;
2, the hydrogen bond donor Quantity: 1;
3, the hydrogen bond acceptors: 3;
4, rotatable bonds: 3;
5, tautomers Quantity:
6, topological molecular polar surface area (TPSA): 46.5;
7, the number of heavy atoms: 8;
8, the surface charge: 0;
9, Complexity: 79.7;
10, isotope atomic number: 0;
11, to determine the atomic stereocenter number: 0;
12, uncertain atom stereocenter Quantity: 1;
13 to determine the chemical bond stereocenter number: 0;
14, uncertain bond stereocenter number: 0;
15, Calcium lactate bonded unit: 1.

ethyl lactate


Colorless liquid, a slight odor. Miscible with water, Sodium lactate in alcohol, aromatics, esters, hydrocarbons, oils and other organic solvents. Flammable, explosive case oxidants. For spices, food, but also as a solvent. Usually consists of lactic acid and ethanol in the presence of sulfuric acid esterification.

industrial sectors lactate

(1) L-lactate is also widely used as a skin care moisturizer to keep the skin moisture, reduce wrinkles;
(2) Sodium lactate is a natural moisturizing factor, a quarter of the stratum corneum of human skin, a composition of lactate. Lactate used in cosmetics can be formed with other chemical components to prevent skin hydration water evaporation film, easy to wet the skin quality, prevent wrinkles, skin care products are widely used as a moisturizing agent. Lactic acid is also used as the pH adjusting agent. L-lactate can be used as a new generation of skin whitening agents, when used in conjunction with other skin whitening agents can produce a synergistic effect.
(3) Sodium lactate as a moisturizer for a variety of bath wash supplies, such as bath gel, bar soap and buffered lactic acid honey. The liquid soap, shampoo and soap can be used as a pH adjusting agent. Also, add in the bar soap can reduce the loss of water during storage, thus preventing the soap dry;

sodium lactate in the medical field

(1) primarily as sodium lactate injections used in the medical field, and its main function is to regulate the body replenish fluids and electrolyte balance, sodium lactate injection can be lifted due to dehydration caused by diarrhea and diabetes and gastritis caused by poisoning.Sodium lactate  was used supplemented parenteral / fluid or electrolyte solution is widely used for continuous renal patients movable peritoneal dialysate (CAPD), and in general used as artificial kidney dialysis;
(2) intravenous injection of sodium lactate used as electrolytes and dialysis thereof, and intestinal disinfectant mouthwash containing agents injected into the bladder etc.;
(3) Sodium lactate is also widely used as a liquid preparation Green, made of injection for the treatment of metabolic acidosis;
(4) sodium lactate can be very effective in the treatment of skin disorders. Such as: dry skin disease caused by extremely dry symptoms. Calcium lactate and lactate with anti-microbial effect, and is applied to anti-acne products. They are usually many other active ingredients in combination, produce a synergistic effect.

sodium lactate in the medical field

(A) primarily as sodium lactate injections used in the medical field, and its main function is to regulate the body replenish fluids and electrolyte balance, sodium lactate injection can be lifted due to dehydration caused by diarrhea and diabetes and gastritis caused by poisoning. Sodium lactate was used supplemented parenteral / fluid or electrolyte solution is widely used for Calcium lactate renal patients movable peritoneal dialysate (CAPD), and in general used as artificial kidney dialysis;
(2) intravenous injection of sodium lactate used as electrolytes and dialysis thereof, and intestinal disinfectant mouthwash containing agents injected into the bladder etc.;
(3) Sodium lactate is also widely used as a liquid preparation Green, made of injection for the treatment of metabolic acidosis;
(4) sodium lactate can be very buffered lactic acid in the treatment of skin disorders. Such as: dry skin disease caused by extremely dry symptoms. Lactic acid and lactate with anti-microbial effect, and is applied to anti-acne products. They are usually many other active ingredients in combination, produce a synergistic effect.

sodium lactate food sector

(1) do emulsifiers, humectants, flavor-improving agent, quality-improving agent, Sodium lactatet synergist and pH adjusting agent is widely used in meat and food processing industry, to enhance the flavor, inhibit the growth of pathogenic bacteria in food, extend product shelf life;
(2) sodium lactate as a food preservative, flavoring agent, antifreeze, moisturizing agent, has been replaced in the foreign part of sodium benzoate as a preservative used in the food industry. lactic acid powder compared with sodium benzoate, sodium citrate, sodium sorbate, there is not the same match advantage. Especially in meat products has the following significant effects: 1, to extend the shelf life: extended from 30 to 100%, or even longer; 2, inhibit pathogens in food, such as: HT Escherichia coli, Listeria monocytogenes bacteria, bacteria such as Clostridium botulinum bud growth, thereby increasing food security; 3, enhance and maintain the flavor of the meat; 4, as a salt can not only reduce the amount of sodium chloride, and sodium lactate people on low-salt heart disease, high- patient blood pressure, kidney patients, more secure. For example, preparing a balanced fitness potassium and sodium salts.

Calcium Lactate Product

Lactate used for infant nutrition research and development. According to modern preventive medicine theory, developed a scientific Calcium lactate lactate microcrystalline powder, is based on the children
The physiological characteristics of tailor-developed calcium microcrystalline powder drink mixes, microcrystalline powder is more suitable for children's delicate stomach, easier to absorb and digest. Especially with vitamin D and a variety of efficient probiotic growth factor - bifidus factor (FOS, GOS) as the absorption enhancers, and the use of advanced biological extraction technology cryogenic purification production workshop in one hundred thousand refined and into; quality fine distinctions, Ethyl lactate science, on the calcium absorption rate went up to a new level, make the baby easily absorbed. Brewed convenient, widely respected and young parents won great favor for you to feed your baby more scientific and professional service.

Calcium lactate product features and consumption methods

Product Features: This product is super anhydrous glucose as the main raw material, does not contain sugar ferrous lactate, there will be added to the water crystallization phenomena, the proposed first milk, rice flour, rice cereal reconstituted good or warm water before mixing the product together.
Edible method :6-12 months each one (10g) ,1-3 years old every 2 (20 g), 2 to 3 times a day, add 100-150 ml of warm water and dissolved with stirring to drink, but also can be added to zinc lactate milk powder, rice flour or rice cereal mixed with food, every time after eating Please sealed to prevent moisture caking.

Calcium Lactate Product

Drug Name lactate
Pinyin Rusuangai
Pinyin CALCIUM LACTATE
Source (MF) and standard product α-hydroxy calcium propionate pentahydrate. Included C6H10CaO6.5H2O should be 98.0 ~ 103.0%.
Characters White or almost white crystalline or granular powder; almost odorless; slight weathering.
This product is soluble in hot water, dissolved in water, in Ethyl lactate, chloroform or ether, almost insoluble. According to modern infant physiological characteristics and dietary habits, developed a scientific feeding baby with complex prebiotic ingredients "lactate glucose" products using the highest quality grade anhydrous glucose as raw materials, in particular, add calcium lactate, zinc, iron and other vitamins nutrients to the latest scientific combination of advanced production technology refined tastes sweet, brewed Calcium lactate, young parents the ideal choice for a new generation of infant nutrition.

Drug Information

Category calcium.
Storage sealed.
Preparation of ferrous lactate lactate tablets
Main ingredients: calcium lactate.
Properties: tablets.
Indications: for the prevention and treatment of calcium deficiency such as tetany, bone hypoplasia, rickets and tuberculosis, pregnant and lactating women, calcium supplement.
Usage and dosage: oral every adult 1-4g, pediatric 0.3-0.6g, 1 day 2-3 times. To simultaneously serving of vitamin D (10,000 units daily) to prevent calcium malabsorption Ethyl lactate.
Adverse reactions and attention:
Specifications: tablet: Each tablet 0.25g, 0.5g. Calcium Mother: Each 0.5g, sweet and delicious, suitable for children.
Manufacturer: Lingbao Yuxi Pharmaceutical Co., Ltd.
Whether the Medicare drug: Medicare
Whether non-prescription drugs: non-prescription

2013年7月20日星期六

Identification of calcium lactate

The product of the aqueous Sodium lactate with calcium

lactate (Appendix Ⅲ) differential response.
Determination To about 0.3g, accurately weighed,

add water 100ml, heated to dissolve, let cool,

add sodium hydroxide solution 15ml with calcium

purpurin indicator about 0.1g, with ethylene

diamine tetra-acetic acid buffered lactic acid titrant

(0.05mol / L) titration until the solution

changes from purple to pure blue. Each 1ml of

ethylene diamine tetra acetic acid disodium

titrant (0.05mol / L) is equivalent to 15.42mg

of C6H10CaO6.5H2O.

Calcium lactate inspection methods

Acidity
Take this product 1.0g, add boiling over

dissolved in 20ml warm water, let cool, add 2

drops of phenolphthalein indicator Sodium lactate and

sodium hydroxide solution (0.1mol / L) 0.50ml,

should be significantly pink.
Chloride
Take this product 0.10g, according to inspection

(Appendix Ⅷ A), with a standard sodium chloride

solution 5.0ml control solution made, shall not

be thicker (0.050%)
Sulfate
Take this product 0.40g, according to inspection

(Appendix Ⅷ B), made with standard potassium

sulfate solution 3.0ml control solution may not

be thicker (0.075%).
Barium salt
Take this product 1.0g, 20ml water to dissolve,

is divided into two equal parts, one as a

control tube, another plus calcium sulfate

solution 1ml, for 15 magnessium lactate, compared with the

control tube, not thicker.
Molysite
Take this product 0.50g, add water 25ml,

dissolved by heating in a water bath, let cool,

according to inspection (Appendix Ⅷ G), with

the standard iron solution 2.5ml were made using

the same method was compared to no deeper

(0.005%).
Heavy Metal
Take this product 1.0g, add 15ml of water and

acetate buffer (pH3.5) 2ml micro heat dissolved,

let cool, add water to make into a 25ml,

according to inspection (Appendix Ⅷ H first

law), containing heavy metals should not exceed

one hundred ten ten buffered lactic acid.
Arsenic
Take this product 1.0g, 5ml hydrochloric acid

dissolved in 23ml of water, according to

inspection (Appendix Ⅷ J first law), shall meet

the requirements (0.0002%).

Calcium lactate content analysis

Weigh calcium lactate equivalent (C6H10CaO6)

about 350mg of the Sodium lactate, dissolved in dilute

hydrochloric acid solution containing 2ml (TS-

117) in 150ml of water. Under stirring

(preferably with a magnetic stirrer) with 50ml

burette added 0.05mol / L EDTA disodium

approximately 30ml, plus sodium hydroxide

solution (TS-224) 15ml and hydroxy phenol blue

indicator 300mg, Lactic acid titration until the

blue color finish. Per ml, 0.05mol/LEDTA

disodium equivalent of calcium lactate

(C6H10CaO6) 10.91mg.

Preparation of calcium lactate

1, fermentation
Calcium carbonate as a neutralizing agent for

lactic acid fermentation broth with lime water

and after secondary crystallization, the direct

production of lactate. Zinc lactate

fermentation feedstock liquid or paste of rice

flour can be used (corn flour) dual enzymatic

hydrolysis, the specific reference to lactic

acid fermentation.
2, and in France
Sodium lactate at 50% of the product was added

calcium hydroxide or calcium oxide for

neutralization reaction, and then filtered to

remove insoluble impurities, and then cooling

crystallization, separation, drying products.

This process is simple, but the cost is higher.

2C3H6O3 + Ca (OH) 2 → (C3H5O3) 2Ca +2 H2O
3, gelatinization of rice by high pressure,

diluted with water cooled to 50-53 ℃, access

Aspergillus and Lactobacillus delbrueckii,

lactic acid buffered lactic acid metabolites, calcium

phosphate and then added to obtain a crude

calcium lactate, and finally purified , or with

calcium carbonate and dilute acid solution, and

then the solution was evaporated in the system.

Refining process is the use of magnesium

hydroxide and magnesium hydroxide reacts with

calcium, it is the nature of cohesion, so that

part of the fermentation broth and protein

impurities removed after condensation, and then

concentrated in vacuo, crystallization, refining

lactate.

Calcium Lactate Applications

1, used as a food additive, child nutrition food

supplements, medical care for calcium

supplement.
2, calcium lactate is a good food calcium

Sodium lactate, calcium absorption better than

inorganic. Can be used in infant food, usage is

23 ~ 46g/kg; in grains and their products for 12

~ 24g/kg;, drinking fluids and milk drinks for 3

~ 6g/kg. Also for buffered lactic acid powder leavening

agents and buffers.
3, for calcium nutrition fortifier for bread,

cakes, etc. buffer, leavening agent. Also be

used for bread, cakes, pasta, powdered milk

market system, tofu, miso, pickled products. As

with other calcium supplements which are easily

absorbed. As drug use, can prevent calcium

deficiency disease, such as rickets, tetany, and

women's pregnancy and lactation required calcium

supplement.

Calcium Lactate

Lactate, MF: CH3CHOHCOO2Ca · 5H2O Molecular

weight: 308.3. White Sodium lactate or powder, no

odor, slight weathering, soluble in water,

insoluble in ethanol, ether and chloroform. Has

a high solubility, dissolution speed, high

bioavailability, good taste, is widely used in

dairy, beverage, food, Calcium lactate care products and

other fields.

Lactate study new solutions

In the process of intense exercise the body

needs a lot of energy. Then the body tissue

removal of lactic acid buffered lactic acid lactic acid

than high speed, increased lactate concentration

within the organization. The significance of

this process is needed reconstruction glycolysis

nicotinamide adenine dinucleotide (NAD) to

maintain ATP production, and improve a steady

stream of energy for the movement, the process

can be described as [5]:
Pyruvate + NADH + H → lactate + NAD
Unlike the general description of the error

increase in lactate concentration in itself does

not cause acidosis, nor is it cause muscle

soreness. Lactic acid in the human body can not

release a proton, so there is no acidity. The

human body glycolytic pathway analysis show that

this process does not lead to zinc lactate.

Strenuous exercise acidosis caused when there is

another reason.
Adenosine triphosphate is split in the release

of energy is that it releases a proton. These

protons are leading causes of acidosis. In the

intense aerobic metabolism during exercise can

not guarantee the production of adenosine

triphosphate, so anaerobic metabolism begins.

Ethyl lactate can produce a large number of

adenosine triphosphate, adenosine triphosphate

which the release of a large number of protons

in the decomposition, reducing the pH of the

tissue, causing acidosis. This is a strong

muscle soreness during exercise one of many

reasons. It was considered by the strong ion

concentration gradient can cause lactic

acidosis, but the study of this process is

imperfect, it is unclear whether there.

Man and lactic acid

For the human body, the material ferrous lactate of

lactic acid, while maintaining the temperature

of the body movement and body heat of the waste

generated in the process. Our body needs to

survive most of the energy from the sugar. Blood

glucose as needed to the various organs of the

combustion heat generated. This process will

produce water, Calcium lactate dioxide and pyruvic acid,

pyruvic acid and lactic acid generated after

hydrogen bonding. If the body energy metabolism

can be normal, no accumulation of blood will be

taken to the liver, and further decomposed into

water and carbon dioxide, heat, fatigue is

eliminated.
If the motion is too intense or prolonged, or

physical decomposition of lactic acid deficiency

in essential vitamins and minerals, the body too

late to be processed lactic acid, resulting in

the accumulation of lactic acid. Too much lactic

acid will weakly alkaline body fluids acidic,

affecting the smooth absorption of nutrients and

oxygen to cells, weakening the normal function

of cells. Accumulation of lactic acid in muscle

contraction will occur, thus squeezing blood

vessels, making poor blood flow, resulting in

muscle aches, chills, headache, heavy flu.

Accumulation of lactic acid in the initial cause

soreness and fatigue, if the long-ignored,

resulting in acidic and may cause serious

illness.
Some people used to sleep late on holidays to

eliminate fatigue, which is invalid. Use

chemicals only seek temporary relief, but also

have side effects. The correct way is to use the

appropriate exercise, especially stretching

exercises to relax the magnessium lactate, promote blood

circulation, select the equalizer light

nutrition, especially foods rich in B vitamins,

plus the quality of sleep, it will get the best

effect.

2013年7月19日星期五

agricultural livestock industry uses

1) Optical purity of more than 99% of lactic

acid, the pesticides used in the production

release of pesticides, such as herbicides, with

non-toxic to crops and soil Sodium lactate and

efficient;
2) lactic acid polymer for the production of

agricultural film, plastic film can replace it,

let the soil can absorb bacterial decomposition,

conducive to environmental protection;
3) Lactic acid is also used for green fodder

storage agent, forage maturation agent;
4) in swine and poultry feed as growth

promoters. Lactic acid can reduce the PH value

of the stomach, digestive enzymes play

activated, the role of improving the acid

digestion, and the growth of buffered lactic acid

intestinal epithelium. Piglets after weaning

feed containing acidifier few weeks to feed

their weaning period can be increased by 15% in

weight;
5) Lactic acid inhibit microbial growth.

Lactation period of the pig will be infected

with by E. coli and Salmonella diseases caused

by, in the feed to join lactic energy prevent

the piggy under the the gastrointestinal tract

growth of pathogenic bacteria;
6) lactic acid can be used as a preservative and

to enhance feed forage, grain and meat by-

products processed products of microorganisms

stabilizer;
7) in drinking water in poultry and pig adding

lactic acid, can effectively inhibit the growth

of pathogenic bacteria, animal weight gain

speed.
Toxicity protection pure non-toxic. Its salts as

long as not too toxic heavy metal salts. Rat

oral LD50 is 3730mg/kg.

Lactate cosmetics industry uses

1) Since L-lactic acid is the skin's natural moisturizing factor inherent part of many Sodium lactate care products are widely used as a moisturizing agent. L-lactic acid is the most effective one AHA and little irritation;
2) Since the L-lactic acid naturally present in the hair, is to make the hair shiny surface, so often used as hair care products of lactic acid pH adjusting agents;
3) lactic acid can be used as a humectant for a variety of bath wash supplies, such as potassium lactate parts bath gel, bar soap and moisturizing honey. The liquid soap, shampoo and soap can be used as a pH adjusting agent. In addition, lactic acid added to the bar soap can reduce the loss of water during storage, thus preventing the soap dry.

other industrial uses

1) lactic acid in the fermentation industry for controlling the pH and increasing the purity fermentation;
2) in the cigarette industry can keep the tobacco moisture, removing impurities in tobacco, changing tastes, raising tobacco grades, lactic acid and nicotine in nicotine can reduce harmful ingredients to improve the quality of tobacco;
3) in the textile industry for processing fibers,Ethyl lactate the fibers can be easily pigmented increase gloss, so soft to the touch;
4) in the paint ink industry as a pH adjusting agent and synthetic agents; in biodegradable plastic fiber industry is new material polylactic acid PLA raw material of choice;
5) The polylactic acid may be used as a starting material, producing a new generation of biodegradable plastics;
6) In the leather industry, lactic acid can be stripped of lime and calcium in leather, the leather soft and fine, which made of high quality leather;
7)Lactic acid acid has a unique due to the complexation constants of nickel, nickel plating is often used, which at the same time as the plating bath in the acid buffer and stabilizers. In the microelectronics industry, its unique of high purity and low metal content meet the semiconductor industry for high quality requirements of, it as a safe organic dissolving agent can be used for photosensitive material cleaning;
8) lactic acid as a pH adjusting agent and synthetic agents can be used in various water-based coating of the adhesive system. Such as: electric plot substance of the coating. Lactic acid products low boiling point, very applicable to Yu as a Gao solid coating established safety buffered lactic acid systems. Lactic acid product family for the production has good a fluid performance containing high solids coatings provide an opportunity;
9) such as the role of lactic acid has a cleaning detergent for washing cleaning products than traditional organic detergents better performance, so it can be used in many cleaning products. Such as: toilets, bathrooms, coffee machine's cleaning agents. Lactic acid has anti-microbial, and when it and other anti-microbial agents such as ethanol, with the use of a synergistic effect.

Medicine use

1) In the wards, operating rooms, laboratories and other places in steam sterilization using lactic acid, can effectively kill bacteria in the air, decrease the disease, to improve health purposes;
2) widely used as a potassium lactate in medicine, the carrier, cosolvent, pharmaceutical preparation, pH adjusting agent;
3) a polylactic acid obtained by polymerizing lactic acid, polylactic acid can be pumped into a spun into a line, this line is a good surgical sutures, seam healing without stitches, degrade into lactic acid can be automatically absorbed by the body, without adverse consequences. In particular, yes in vivo surgery sutures, absolve secondary surgery stitches of trouble. Sodium lactate macromolecular compound can be made into adhesive agent in the organ transplants and bonesetting middle application of;
4) lactic acid can be directly formulated into pharmaceutical or health products everyday use; such beauties private parts shower gel formulation is developed by European experts, for the manufacture of a mature woman vaginal lactobacilli slow, adding lactic ingredients, maintaining good vaginal self-cleaning effect.
5) Section muscle activity and fatigue restraining effect.

food industry uses

1) Preservation of lactic acid has a strong effect, can be used in wine, beverage, meat, food, potassium lactate, vegetables (olives, cucumbers, pearl onions) marinated and canning, food processing, fruit storage, with the regulation pH, antibacterial, extend shelf life, seasoning, keep food color, improve product quality and other effects;
2) seasoning, the increased acidity of lactic unique delicious food, in salads, soy sauce, vinegar, seasoning adding a certain amount of lactic acid, can maintain the stability of the magnessium lactate products, security, while making the milder taste ;
3) As a mild lactic acidity is moderate, but also as a careful deployment of soft drinks and juices preferred acidifying agent;
4) in the brewing of beer, adding the appropriate amount of lactic acid to adjust the pH to promote both glycosylated, is conducive to yeast fermentation, improve the quality of beer, but also increase the beer flavor, extend shelf life. In the liquor, sake and wine used to adjust the pH, to prevent bacteria growth, enhance sour and refreshing taste; 5. Buffered lactic acid can be used in hard candy, fruit candy and other confectionery buffered lactic acid , moderate acidity and sugar conversion rate. Lactic acid powder can be used on all kinds of candy powder, sour agent as a powder;
5) Natural Lactic acid is a natural inherent ingredient in dairy products, dairy taste and it has good anti-microbial effect, has been widely used in the deployment of yogurt cheese, ice cream and other foods, dairy sour agent as acclaimed;
6) for the production of lactic acid powder is a direct sour shallots regulator. Lactic acid is a natural fermentation, so you can make bread has a unique taste; lactic acid as a natural acidity regulator, bread, cakes, biscuits and other baked goods used for seasoning and antibacterial effects, and can improve the quality of food, keep the color , to extend shelf life.

lactate enzymatic method

(A) propionic acid chloride Ethyl lactate conversion
The University of Tokyo, Kawasaki [6] and other studies of the use of purified L-2-halo acid dehalogenase and DL-2-halo acid dehalogenase were acting on the substrate L-2-chloro-propionic acid and DL- 2 - chloro acid, L-lactic acid obtained bittern off or D-lactic acid. L-2-halo acid dehalogenase catalyzed L-2-chloropropionic acid, and DL-2-halo acid dehalogenase catalyzed both L-2-chloropropionic acid, but also the catalytic L-2-chloropropyl generate the corresponding optically active acid, catalytic conversion simultaneous configuration.
(2) enzymatic conversion of pyruvate
Lactate dehydrogenase from the highest activity of Lactobacillus DSM20196 confusion cells obtained in D-lactic acid buffered lactic acid, a non-optically active pyruvate as substrate D-lactic acid can be obtained.
Industrial production of lactic acid fermentation method and the method is mainly synthesis. Because fermentation process is simple, abundant raw materials, develop and become more mature earlier lactic acid production methods, lactic acid production accounts for about 70 or more, but long cycle, only batch or semi-continuous production and quality of domestic non-lactic fermentation to international standards. Chemical method can achieve large-scale continuous production of lactic acid and lactic acid synthesis has also been the U.S. Food and Drug Administration (FDA) approval, but the raw materials are generally toxic, does not meet the requirements of green chemistry. Enzymatic process is complex, and its industrial application needs further study.

Lactate synthesis

Synthesis method of potassium lactate lactic lactonitrile, acrylonitrile method, acid method, acrylic method, etc., for industrial production lactonitrile only method (also called acetaldehyde hydrocyanic acid method) and the nitrile method.
(1) Method lactonitrile
Lactonitrile method is the acetaldehyde and hydrogen cyanide cold milk continuously fed to the reactor to generate a nitrile (or directly with the milk as raw material nitrile), with a pump into the milk nitrile hydrolysis reactor, into sulfuric acid and water to make milk nitrilase to give the crude acid. And then give it away crude lactic acid esterification reactor, adding ethanol esterification, distillation, concentration, lactic acid decomposition was fine. American Sterling Chemical Company and Japan Musashino Chemical companies are adopting this synthesis of lactic acid.
(2) acrylonitrile Method
Acrylonitrile and acrylonitrile method is hydrolyzed in sulfuric acid fed to the reactor, and then hydrolysis reactor anyone to esterification reaction with methanol; then after separation of the hydrogen sulfate, the crude ester distillation column, the bottom is Fine ester; then refined into a second distillation column ester, thermal Sodium lactate, bottom too thin lactic acid, concentrated by vacuum to obtain the product.
(3) propionic acid method
Propionic acid method as raw material, through chlorination, hydrolysis of the crude lactic acid; re-esterification, distillation, hydrolysis products. This method is more expensive raw materials, only a few companies such as Japan's road contest manufacturers to adopt. Reaction is as follows:
CH3CH2COOH Cl2 one → CH3CHClCOOH NaOH-→ CH3CH (OH) COOH NaCl

Lactic acid fermentation

Fermentation of Sodium lactate is the main way of lactic acid bacteria, adjust the pH value of about 5, for about 50 or 60dm; C Fermentation three to five days to give the crude acid.
Fermentation of raw materials is generally corn, rice, sweet potatoes and other starch material (also alfalfa, Calcium lactate and other raw materials, research has raised kitchen garbage and recycling fish waste production of lactic acid). Lactic acid fermentation lactic acid production stage to many, but not acid-producing higher-quality and more, mainly Rhizopus and other lactobacilli strains. The fermentation of different strains of different ways, can be divided into the same type of fermentation and shaped fermentation, the actual presence of microorganisms as other physiological activities, may not be simply a certain kind of fermentation pathway.
Fermentation of the same type of fermentation and shaped fermentation.

Physical and chemical properties of lactic acid

Pure Lactic acid liquid, is a colorless to pale yellow liquid. Odorless, hygroscopic. The relative density of 1.2060 (25/4 ℃). Melting point 18 ℃. Boiling point 122 ℃ (2kPa). Refractive index nD (20 ℃) ​​1.4392. With water, ethanol, glycerol miscible, acidic aqueous solution, PKa = 3.85. Insoluble in chloroform, carbon disulfide and petroleum ether. Heating under normal pressure, concentrated to 50%, the part becomes the lactic anhydride, product often contains 10% to 15% of the milk anhydride. As a hydroxyl group and a carboxyl group, under certain conditions, the esterification reaction can occur, the potassium lactate has three.
Toxicity: Rat oral LD50 for 3.73g/kg weight; ADI Unlimited regulations. Lactic acid has three isomers: DL-type, D-type and L-type. The rats were divided into three groups, each dosage dose of 1.7g/kg body weight of DL-type, D-type and L-lactic acid, oral anatomy detected three hours later, DL-lactic acid can increase the liver glycogen , 40% to 95% within 3h absorption and transformation; D-and L-lactic acid in the blood lactate increased, the urine excreted.

Determination of lactic acid - neutralization titration method

Principle of the method: the test sample dissolved in water, and then precision by adding sodium Ethyl lactate solution (1mol / L) 25mL, boil for 5 minutes, add 2 drops of phenolphthalein indicator solution, hot sulfuric acid titration solution (0.5mol / L) titration, and titration of the blank test correction, phenolphthalein indicator solution turns red stop titration, read sulfuric acid titrant, calculate the lactic acid content.
Reagents: (1) water (boiling placed to room temperature)
(2) sodium hydroxide solution (1mol / L)
3 sulfuric acid titration solution (0.5mol / L)
4 phenolphthalein indicator solution
5 methyl red - bromocresol green mixed indicator solution
6 Ethanol
7 benchmark potassium hydrogen phthalate
8 benchmark anhydrous sodium carbonate
Equipment:
Sample Preparation: 1. Sodium hydroxide solution (1mol / L)
Preparation: Take clarified saturated solution of sodium hydroxide 56mL, add boiling over cold water to make into 1000mL.
Calibration: in 105 ℃ drying to constant weight basis of potassium hydrogen phthalate about 6g, accurately weighed, add boiling over cold water 50mL, shake, to try to dissolve; add 2 drops of phenolphthalein indicator solution, with the droplets, close to the end, should make potassium hydrogen phthalate is completely dissolved, the solution was titrated to pink. Each 1mL of sodium hydroxide (1mol / L) is equivalent to 204.2mg of potassium hydrogen phthalate. According to the liquid magnessium lactate potassium hydrogen phthalate and dosage, calculate the concentration of the solution.
Storage: polyethylene plastic bottle, sealed and stored; plug two holes, each hole insert the glass one, one with soda lime tube connected to a suction of the fluid for use.
2 acid titration solution (0.5mol / L)
Preparation: Sulfate 30mL, slowly inject the right amount of water, cooled to room temperature, diluted with water to 1000mL, shake.
Calibration: at 270-300 ℃ drying to constant weight basis anhydrous sodium carbonate is about 1.5g, accurately weighed, add water to dissolve 50mL, add methyl red - bromocresol green mixed indicator solution 10 drops of the droplet to solution from green to purple, boil for 2 minutes, cooled to room temperature and continue the titration until the solution color green to dark purple. Each 1mL of sulfuric acid titration solution (0.5mol / L) is equivalent to 53.00mg of anhydrous sodium carbonate. According to the liquid consumption of anhydrous sodium carbonate dosage, zinc lactate the concentration of the solution, that is, too.
3 phenolphthalein indicator solution
Take phenolphthalein 1g, plus ethanol 100mL dissolve.
4 bromocresol green mixed indicator solution
0.1% methyl red ethanol solution of 20mL, plus 0.2% bromocresol green in ethanol 30mL, shake, that, too.
Procedure: Weigh the test sample 1g, accurately add water 50mL, precision by adding sodium hydroxide solution (1mol / L) 25mL, boiled for 5 minutes, add 2 drops of phenolphthalein indicator solution, hot sulfuric acid titration solution (0.5mol / L) titration, to the solution was pink, and titration of the blank test correction, record consumption of sulfuric acid titrant volume number (mL), each 1mL of sodium hydroxide (0.1mol / L) is equivalent to 90.08mg lactic acid (C3H6O3).
Note 1: "Precision Weigh" means to check the weight should be accurately referred to take the weight of one-thousandth, "precise amount" means the amount of volume accuracy should be in line with national standards for the volume pipettes accuracy requirements.

Lactate Overview

In the ferrous lactate process pyruvate is converted to lactate dehydrogenase L-lactic acid. In general, the lactic acid metabolism and movement is generated continuously, but its concentration is generally not rise. Only in lactate production speed up the process, lactic acid can not be transported in a timely manner when the concentration will increase. Acid transport speed by a series of factors, including monocarboxylic transporter, lactate dehydrogenase concentration and isomeric forms, tissue oxidation. Generally the concentration of lactate in the blood is not in movement 1-2mmol / L, in the strong movement can rise to 20mmol / L.
Generally when an organization's energy through aerobic respiration can not be met, the organization can not get enough oxygen or oxygen can not be fast enough to handle the case of lactic acid concentration will rise. In this case, the pyruvate dehydrogenase can promptly convert pyruvate acetyl coenzyme A, began to accumulate pyruvate. In this case, if the reduction of lactate dehydrogenase pyruvate to lactate is not the case of glycolysis and ATP synthesis is suppressed. The process for the potassium lactate of lactic acid: pyruvate + NADP + H + → lactate + NAD
The significance of this process is needed reconstruction glycolysis nicotinamide adenine dinucleotide (NAD +) to maintain ATP synthesis. Sufficient oxygen in muscle cells of lactic acid can be oxidized to pyruvate, and then directly used as the citric acid cycle of the fuel. It can also gluconeogenesis in the liver through the process Kelibusi cycle into glucose. Bacteria of the genus Lactobacillus can also be lactic acid fermentation. These bacteria can live in the mouth, they produce lactic acid is leading cause of dental caries. Lactic acid is often used in medicine in Ringer's lactate solution in. This is a human blood with isotonic sodium chloride, potassium chloride and a solution of lactic acid in distilled water. In injury, surgery or burns after blood loss often used to supplement the loss of blood lactate Ringer's solution.

Lactate

Pure lactic acid is a ferrous lactate liquid, is a colorless to pale yellow liquid. Odorless, hygroscopic. The relative density of 1.2060 (25/4 ℃). Melting point 18 ℃. Boiling point 122 ℃ (2kPa). Refractive index nD (20 ℃) ​​1.4392. With water, ethanol, glycerin, insoluble in chloroform, carbon disulfide and petroleum ether. Heating under normal pressure, concentrated to 50%, part of the anhydride into milk, thus products often contain 10% -15% of the milk anhydride.