Lactate Overview

In the ferrous lactate process pyruvate is converted to lactate dehydrogenase L-lactic acid. In general, the lactic acid metabolism and movement is generated continuously, but its concentration is generally not rise. Only in lactate production speed up the process, lactic acid can not be transported in a timely manner when the concentration will increase. Acid transport speed by a series of factors, including monocarboxylic transporter, lactate dehydrogenase concentration and isomeric forms, tissue oxidation. Generally the concentration of lactate in the blood is not in movement 1-2mmol / L, in the strong movement can rise to 20mmol / L.
Generally when an organization's energy through aerobic respiration can not be met, the organization can not get enough oxygen or oxygen can not be fast enough to handle the case of lactic acid concentration will rise. In this case, the pyruvate dehydrogenase can promptly convert pyruvate acetyl coenzyme A, began to accumulate pyruvate. In this case, if the reduction of lactate dehydrogenase pyruvate to lactate is not the case of glycolysis and ATP synthesis is suppressed. The process for the potassium lactate of lactic acid: pyruvate + NADP + H + → lactate + NAD
The significance of this process is needed reconstruction glycolysis nicotinamide adenine dinucleotide (NAD +) to maintain ATP synthesis. Sufficient oxygen in muscle cells of lactic acid can be oxidized to pyruvate, and then directly used as the citric acid cycle of the fuel. It can also gluconeogenesis in the liver through the process Kelibusi cycle into glucose. Bacteria of the genus Lactobacillus can also be lactic acid fermentation. These bacteria can live in the mouth, they produce lactic acid is leading cause of dental caries. Lactic acid is often used in medicine in Ringer's lactate solution in. This is a human blood with isotonic sodium chloride, potassium chloride and a solution of lactic acid in distilled water. In injury, surgery or burns after blood loss often used to supplement the loss of blood lactate Ringer's solution.