pathologically elevated lactate

(1) with certain diabetic hypoglycemic lactate levels were significantly increased, the formation of lactic acidosis, and even lead to coma.
(2) circulatory failure and respiratory failure, due to tissue Sodium lactate  glycolytic rate increases, blood lactate is usually more than 7mmol / L, even up to 25mmol / L, lead to coma and lactic acidosis.
(3) severe liver disease, uremia, bacterial infections, arteriosclerotic heart disease, alcoholism, leukemia, severe anemia, lactate levels will rise.
(4) I glycogen storage disease type: glucose metabolism because the body lacks certain enzymes needed, the patient can not be synthesized in the liver break down glycogen utilization, resulting in low blood sugar, low blood sugar stimulate the secretion of adrenaline, which makes muscle glycogen decomposition, produce large amounts of lactic acid.
(5) patients with mitochondrial magnessium lactate , lactic acid concentration before and after exercise vary widely, often clinically lactate difference before and after exercise more than 3 times the disease as an auxiliary diagnostic criteria.