diabetes and lactic acidosis

Diabetes Foundation status, common with mild lactic acidosis, lactic acid may be associated with the oxidation of primary Defects. In addition, insulin deficiency (absolute or relative), the enhanced role of Sodium lactate  causing Lactate production increased. DKA, the blood lactate concentration may be increased several times, increasing metabolic acidosis Poison, DKA when lactic acidosis part may be due to inhibition of hepatic uptake and cyclic ketones
Reduced blood volume due to the inadequate tissue perfusion. Diabetic hyperosmolar nonketotic coma (NHK) than DKA More likely to cause serious LA, total parenteral nutrition and potassium lactate nutrition of lactic acidosis may induce Hair LA,. By total parenteral nutrition ingredients include carbohydrates in addition to glucose, there Fructose or sorbitol (which can be metabolized to fructose). Metabolic acidosis may be the glucose metabolism Direct result. Three-carbon molecule of fructose is metabolized intermediate consumption 2 molecule ATP. In the liver,Reduce the level of high-energy phosphate bond inhibiting gluconeogenesis and stimulating glycolysis