pathogenesis of lactic acidosis

1 septic shock with lactic acidosis septic shock, endotoxin and other bacterial products Initiating a series of metabolic reactions leading to inflammatory mediators, cytokines and Ethyl lactate substances Synthesis and release, damages vasomotor tone, increased microvascular permeability, fluid from capillary blood
Pipe leaks so that the effective circulating blood volume and cardiac output decreased (circulating bacterial products can directly damage Damage left ventricular function). Finally, the systemic blood pressure changes caused by the decline followed, adrenal And increased sympathetic activity and selectivity of vasoconstriction of skin and internal organs (including liver Dirty and kidney) blood flow decreases. The metabolic and ferrous lactate factors leading to increased lactate production Plus. Hilar
Vein blood flow also limits the reduction of the liver uptake of lactic acid. Tissue hypoperfusion reduced oxygen supply To, leading to respiratory chain and oxidative phosphorylation disorders. Inhibition of tissue lactate removal ability.