causes lactic acidosis

LA mostly acquired, due to genetic defects (PDH, the citric acid cycle or respiratory chain defects)Due to "congenital LA" are very rare. . Common causes of acquired LA can be divided into the following Two categories: tissue hypoxia (A type) and non-tissue hypoxia (B type), but clinically, the majority are Type A and LA B-type mixing, related to the generation of lactic acid and proton and clear two aspects. 1.A type ① tissue magnessium lactate  increased vascular permeability and abnormal tension; left ventricular dysfunction, cardiac output
Output decreased; hypotension; ② arterial oxygen content decreased: suffocation; hypoxemia (Pa O2 <35 mmHg); carbon monoxide poisoning; severe anemia. 2.B type ① common diseases: diabetes,Sepsis, liver and kidney failure, cancer, malaria and cholera; ② drugs or toxins:Calcium lactate, ethanol, methanol, cyanide, nitroprusside, nicotinic acid, catecholamines, antipyretic analgesics,
Nalidixic acid, isoniazid, streptozocin new, sorbitol, parenteral nutrition, lactose, theophylline, cocaine, Estrogen deficiency, etc.; ③ genetic diseases: G-6-phosphate dehydrogenase deficiency, fructose 1,6 - two Phosphatase deficiency, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency and lack of oxidative phosphorylation Depression; ④ other cases: to strengthen muscles and grand mal seizures. Diabetes lactic acidosis Is a B-type.